Organocatalyzed synthesis of ureas from amines and ethylene carbonate

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Organocatalyzed synthesis of ureas from amines and ethylene carbonate

Publication year: 2010
Source: Tetrahedron Letters, In Press, Accepted Manuscript, Available online 29 September 2010
Francesco, Saliu , Bruno, Rindone
A new solventless method for the synthesis of symmetrical and unsymmetrical ureas, starting from ethylene carbonate and amines, is reported. 1,5,7-Triazabicyclo[4.4.0]dec-5-ene(TBD) and thioureas have been found to be efficient organocatalysts for this reaction.
Disubstituted and trisubstituted ureas were synthesized from ethylene carbonate and amines under solventless conditions using organic bases as catalysts.

B.O.