Selective deprotection and amidation of 2-pyridyl esters via N-methylation

 

 

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Selective deprotection and amidation of 2-pyridyl esters via N-methylation

przez ScienceDirect Publication: Tetrahedron dnia 10-10-13

Publication year: 2010
Source: Tetrahedron, Volume 66, Issue 45, 6 November 2010, Pages 8667-8671
Shinji, Yamada , Misato, Abe
The 2-pyridyl residue serves as a protecting group for various carboxylic acids. The protecting group is selectively cleaved under mild conditions via N-methylation of the pyridyl group. During the deprotection process, the various functional groups as well as the other ester moieties remain intact. The N-methylated active esters can be subsequently transformed into amides.

 

 

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