K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluorom...

 

 

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K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

przez ScienceDirect Publication: Tetrahedron Letters dnia 10-07-13

Publication year: 2010
Source: Tetrahedron Letters, In Press, Accepted Manuscript, Available online 13 July 2010
Li, Shen , Song, Cao , Jingjing, Wu , Hui, Li , Jian, Zhang , ...
A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes and ammonium acetate in the presence of K2CO3 under solvent-free conditions via sequential Hantzsch reaction/dehydration/dehydrofluorination in a one-pot process was described.

Graphical abstract

A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates via K2CO3-assisted one-pot sequential Hantzsch reaction/dehydration/dehydrofluorination under solvent-free conditions was described.

 

 

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