Development and Scope of the Phenolic Aldol Reaction of 2-Formylpyridines

 

 

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Development and Scope of the Phenolic Aldol Reaction of 2-Formylpyridines

via Synlett by Matthew Whiting, Mark C. Wilkinson, Kathy Harwood on 6/2/09

Synlett
DOI: 10.1055/s-0029-1217325

Abstract

2-Formylpyridines have been shown to be suitable electrophiles for the magnesium-promoted phenolic aldol reaction. Exceptionally mild reaction conditions have been developed and a brief survey of the reaction scope has been conducted. This process gives straightforward access to a range of functionalised 2-hydroxy­phenyl-2-pyridylmethanols and 2-hydroxyphenyl-2-pyridylmethanes via their subsequent reduction.
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© Georg Thieme Verlag Stuttgart ˙ New York

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