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Synthesis
DOI: 10.1055/s-0029-1216878
Abstract
A novel microwave-assisted protocol has been developed for the selective O-alkylation of aromatic imidate systems with various halides under microwave irradiation using silver carbonate as the base. Products were obtained in short reaction time and in excellent yields.
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© Georg Thieme Verlag Stuttgart ˙ New York
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Synthesis
DOI: 10.1055/s-0029-1216871
Abstract
We have developed a versatile and efficient method for copper-catalyzed synthesis of both 2-amino-4()-quinazolinone and 2-aminoquinazoline derivatives. The protocol uses readily available substituted 2-halobenzoic acids, 2-bromobenzaldehyde, 2-bromophenyl ketones and guanidines as the starting materials, inexpensive copper(I) iodide as the catalyst, and the method has important application values for construction of N-heterocycles in organic chemistry and medicinal chemistry.
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© Georg Thieme Verlag Stuttgart ˙ New York
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Table of contents | Abstract | Full text